Intracellular Sensing and Transport of Amino Acids and the Downstream Effects on mTORC1 Activation: Implications for Muscle Protein Synthesis
نویسندگان
چکیده
MPS: Muscle Protein Synthesis; mTORC1: Mammalian Target of Rapamycin Complex 1; mTOR: Mammalian Target of Rapamycin; PI3K: Phosphatidylinositol-3 Kinase; PIP2: Phosphatidylinositol4,5-biphosphate; PIP3: Phosphatidylinositol-3,4,5-triphosphate; PDK: Phosphoinositide-dependent Kinase; 5’-TOP: 5’ terminal oligopyrimidine; eIFs: Eukaryotic Initiation Factors; GAP: GTPase Activating Protein; BCAAs: Branched Chain Amino Acids; HBXIP: Hepatitis B Virus X Interacting Protein; GEF: Guanine Nucleotide Exchange Factor; PA: Phosphatidic Acid; PLD1: Phospholipase D; GDH: Glutamine Dehydrogenase; IPMK: Inositol Polyphosphate Multi-Kinase; ULK1: Unc-51-Like Kinase 1
منابع مشابه
The effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways gastrocnemius muscle of type 2 diabetic rats
Background: The pathway of mTORC1 is one of the most important pathway in protein synthesis, and type 2 diabetes and insulin resistance can lead to inhibit this pathway. The aim of this study was to investigate the effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways in gastrocnemius muscle in type 2 diabetic rats. Materials and met...
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